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Introduction: Pneumonia is the second leading cause of nosocomial infections and the most common cause of hospital death. Recently BNP (B-type natriuretic peptide) has been used as a marker for severity evaluation of community acquired Pneumonia’s (CAP) patients. The aim of this study is to determine the relationship between pro-BNP levels with chest radiographic changes during the course of treatment of patients with Pneumonia.
Materials and Methods: This cross-sectional study was carried out on 30 patients with CAP in Hazrat-e Rasoul Hospital of Tehran in the year 2016. Demographic data, Laboratory findings including ProBNP level and Chest Radiographic findings were recorded. Data were analyzed then using SPSS software ,version 20.
Result: Out of thirty patients, 43.3% (13 cases) were male and 56.7% (17 cases) were female. Patients were at the age of 25 to 85 years old. The mean age of patients was 64.63 ± 14.40. The baseline BNP level and the level of BNP six weeks after treatment were 237.77 ± 160.95 and 226.33 ± 156.74, respectively. There was no significant difference between baseline BNP level and the level of BNP six weeks after treatment (P=0.236). After treatment, 90% of patients were cleared from chest involvement. There was a significant difference between the areas of lung involvement during the measurement of baseline BNP level with the level of BNP six weeks after treatment (P <0.001).
Conclusion: There was no significant difference between the level of baseline BNP and the level of BNP six weeks after treatment. After 6 weeks treatment, there was no evidence of chest involvement in most patients. The lack of significant correlation between BNP levels and the severity of pneumonia could be due to small sample size of the study. Therefore, it is suggested that the study to be conducted with a larger sample size and BNP levels compared with healthy individuals.