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Introduction: Because of high prevalence and important effects of nocturnal enuresis in children's life and presence of some refractory cases that are not well-responders of standard treatment, this urodynamic and ultrasound study was done in children with mono-symptomatic primary nocturnal enuresis (MSPNE) before and after six months of therapy.
Materials and Methods: From May 2011 to May 2015, 259 children (142 boys and 117 girls) with MSPNE according to the International Children’s Continence Society guidelines and more than three wet nights per week were chosen for this non-randomized clinical trial. They were treated with desmopressin (20 μg intra-nasally at bedtime) and enuresis alarm. Six months after the treatment we divided the participants into two groups of non-responders and well-responders and repeated the evaluations.
Result: Urodynamic (like low bladder compliance and capacity and bladder outlet obstruction) and ultrasound abnormalities (like high and low bladder volume and wall thickness index percentage, abnormal bladder wall thickness) were more common in the non-responder group.
Conclusion: Urodynamic study combined with ultrasound evaluation can be more helpful in case of refractory enuresis by detecting dysfunctional voiding, which consist of a large percentage of these patients. These investigations can be used as a predictor of treatment response and need for more evaluation or other kinds of treatments.